| Ballroom C (Washington DC Convention Center) | |||
| Alpha-2 Adrenergic Receptors in Acute and Chronic Pain: Actions and Interactions | |||
| Agonists acting at alpha-2 adrenergic receptors (α2ARs) are powerful analgesic and anti-hyperalgesic agents. In addition, they interact synergistically with other analgesic agents, a property important in pain management as synergy-enabled decreases in dose may simultaneously minimize side effects and increase efficacy. α2ARs agonists are especially effective in the treatment of neuropathic pain and are used as an alternative in cases where opioid efficacy is limited. However, more extensive clinical use has been limited by associated side effects such as sedation. The use of strategies to increase the therapeutic utility of α2ARs agonists such as co-administration with opioids or other inhibitory agents and the use of alternative routes of administration continue to produce promising results. In this session, we will first explore these actions and interactions at the behavioral, pharmacological and molecular levels. Second, we will explore recent insights into the role of brain-derived TNFα in peripheral modulation of norepinephrine release and α2ARs function. Changes in those systems that accompany peripheral nerve injury may present an ideal target for future therapeutic development. | |||
| Moderator: | George L. Wilcox, PhD | ||
| Presenters: | Dennis Paul, PhD Tracey A. Ignatowski, PhD Laura S. Stone, PhD | ||
| Alpha-2 Adrenergic Receptors in Acute and Chronic Pain: Actions and Interactions George L. Wilcox, PhD | |||
| Serotonin and Opioid receptor Interactions with alpha2 Adrenoceptors in the Production of Spinal Analgesia Dennis Paul, PhD | |||
| Brain-derived TNF Affects a2-Adrenergic Functioning on Neurons and Peripheral Macrophage Tracey A. Ignatowski, PhD | |||
| Alpha-2 Adrenergic Receptors in Acute and Chronic Pain: Actions and Interactions-3 Laura S. Stone, PhD | |||
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