| Room 204AB (Washington DC Convention Center) | |||
| Long Term Implications of Repeated Pain in Neonates | |||
| Premature infants are routinely exposed to pain and inflammation resulting from multiple invasive medical procedures during neonatal intensive care treatment. It is unknown how exposure to early insult during this time of increased plasticity alters the development of the central and peripheral nervous system, and influences future childhood and adult behaviors. Dr. Anne Murphy will present data in rodents demonstrating that persistent inflammatory pain induced on the day of birth results in profound changes in adult sensory thresholds and response to re-injury in adulthood. Sex differences and mechanisms contributing to these changes in sensory threshold will be presented. Dr. Gayle Page will present data in rats showing the impact of repeated needle pricks during the first 8 days of life on pain sensitivity as well as neuroendocrine responsiveness to acute painful stress in mature males and females. Dr. Anna Taddio will present human data demonstrating that untreated pain in the neonatal period leads to hyperalgesia and conditioning to future pain responses. The potential effects of pre-emptive analgesia will be discussed. Together, this symposium will highlight findings in both animal and human research on the long-term impact of repeated pain and will address potential mechanisms that contribute to these permanent changes. | |||
| Moderator: | Anne Z. Murphy, PhD | ||
| Presenters: | Gayle G. Page, DNSc Anna Taddio, PhD Anne Z. Murphy, PhD | ||
| The Long Term Consequences of Early Repeated Pain Experiences on Stress Responsiveness and Pain Sensitivity at Maturity Gayle G. Page, DNSc | |||
| Long Term Implications of Repeated Pain in Neonates-1 Anna Taddio, PhD | |||
| Influence of Neonatal Injury on Adult Sensory Thresholds Anne Z. Murphy, PhD | |||
[Handout]
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