A major limitation in the research of benefits from multidisciplinary pain rehabilitation is the lack of data on long-term outcomes based on opioid use and withdrawal in chronic noncancer pain patients. Such long-term research is needed to assess the benefits for opioid and nonopioid groups after rehabilitation and how these groups compare over time. In a longitudinal nonrandomized 2-group design, patients participating in a three-week comprehensive pain rehabilitation program were compared at admission (Time One) and six-months post-treatment (Time Two) by admission opioid status (taking opioids vs. not taking opioids). Demographic comparisons between the two groups included age, gender, marital status, and ethnicity. Participants completed the following standard measures at both time points: Multidimensional Pain Inventory (MPI), Pain Catastrophizing Scale (PCS), Pain Anxiety Symptoms Scale (PASS), and the CES-D. The study sample consisted of 200 patients of which 87 (43.5%) were using opioids daily at admission. All patients taking opioids at admission were tapered off these medications by completion of treatment. Results show no demographic differences between the two groups (p's>.05). Time One comparisons were significant for pain severity (p<.01), life interference (p<.01), catastrophizing (p<.05), and anxiety symptoms (p<.01) with the opioid group reporting more dysfunction. Significant symptom improvement at Time Two was reported by all participants regardless of opioid status or symptom severity at Time One. These data suggest patients with severe pain-related symptomatology while taking opioid maintenance therapy may demonstrate significant symptom improvement up to six-months post-treatment. More importantly, the incorporation of opioid withdrawal does not appear to impact positive treatment outcomes.