This study characterizes the quality, severity, personal significance and personal health burden of chronic pain associated with post-polio syndrome (PPS) among adults. Post-polio syndrome (PPS) is a condition first named in 1984 to describe a spectrum of symptoms that occur between 20 and 40 years following acute infection with the poliomyelitis virus. Key symptoms include abrupt or gradual onset of new muscle weakness, increased fatigue, and muscle and joint pain. Over 600,000 Americans and millions worldwide are estimated to have PPS. No single medication relieves the symptoms of PPS; however, rehabilitation including pacing and light, graded exercise have been advocated. Because PPS quality of life studies typically incorporate only single-item pain severity measures, little is known about the sensory qualities of the pain and the consequences of the pain as individuals reach middle age. Formal characterization of PPS pain as a mixed neuropathic-nociceptive condition might open new avenues for intervention. In this initial exploration of PPS-related pain, adults (n=27) with an established diagnosis of PPS participated in semi-structured interviews regarding pain experience and pain management across lifespan events, and completed validated questionnaires regarding location, severity, sensory quality, medical and complementary treatments for pain, and satisfaction with treatments. Results show that PPS is characterized by muscle and joint pain with primarily nociceptive but also neuropathic (stabbing, tingling) qualities. Lower back pain is the most common additional pain concern not directly associated with muscles or joints. Pain is a daily experience for most participants, ranging from mild to severely limiting pain. Participants described having evolved a spectrum of personal strategies to manage pain, including self pacing, medication, assistive devices and complementary medicine. Results and insights gained from qualitative analyses of the interview material and quantitative measures of pain quality and pain-related burden will be presented.